An Elastic Network Model (ENM) describes a protein as a structured elastic object at a coarse-grained level. The most widely used ENMs represent a protein by its Cα atoms connected by springs. We have been developing, evaluating, and applying ENMs for many years, with applications including in particular the interpretation of low-resolution protein structures and the analysis of conformational transitions.
Structural flexibility in proteins: impact of the crystal environment
Hinsen K, Petrescu A, Dellerue S, Bellissent-Funel MC, Kneller GR
Harmonicity in slow protein dynamics
Chem Phys. 2000;261(1–2):25–37
Analysis of domain motions by approximate normal mode calculations